Huaiqihuang (HQH) Granule
Huaiqihuang (HQH) Granule
Key words:
Huaiqihuang (HQH) Granule
Classification:
- Details
- Prescription efficacy
- Immunization
- Pharmacological characteristics
- Synopsis (of a play or film)
- Problem solving
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- Commodity name: Huaiqihuang (HQH) Granule
HQH Granule possesses both anti-inflammatory properties and bidirectional immune regulation, effectively ensuring immune balance within the body.
Balanced Immunity, Healthy Life
Initially launched in the market for "recurrent respiratory infections in children," HQH Granule received favorable evaluations. Given the close relationship between recurrent respiratory infections and the recurrence of childhood asthma, HQH Granule has also been recognized for its efficacy in treating childhood asthma.
Inspired by its effectiveness in treating both of the two conditions, scholars began conducting extensive basic research on kidney disease models using the API of “HQH Granule” and achieved excellent results. Clinical evaluations for its use in treating pediatric kidney diseases were consistent with the basic research findings. Similarly, the treatment of adult kidney diseases poses challenges for both patients and healthcare professionals. HQH Granule was used to treat some patients, and it controlled their hematuria, proteinuria, and repaired renal function within a short period. Subsequently, it showed promising results in treating a series of related diseases in pediatric hematological systems, such as immune thrombocytopenic purpura, immune neutropenia, aplastic anemia, and acute and chronic leukemia. It also demonstrated excellent signs in the treatment of autoimmune diseases such as immune lupus erythematosus, Sjögren's syndrome, and rheumatic diseases.
Looking at the above pathways, HQH Granule has shown good efficacy in treating immune diseases. As we all know, immunity is present in all tissues and organs of the human body. Once immunity is compromised, corresponding tissues and organs can develop diseases that are often difficult to treat. So, what is immunity? Why are immune diseases so difficult to cure?
The fundamental concept of immunity is that the organism recognizes the “self” and the “not-self” and generates an immune response to remove the “foreign” antigen or induce immune tolerance, so as to maintain the stability of its own internal environment. This involves immune recognition, immune response, immune tolerance and immune regulation, and the structure, links and steps are extremely complex. When any of these recognition, response, tolerance, regulation, etc. go wrong, immune diseases may occur. In layman's terms, when the body fails to recognize its own tissues, its own tissues may be attacked or injured, and this is an autoimmune disease. And when some foreign substances such as bacteria, viruses, proteins can recognize or can not recognize, after recognition of the response is too strong or too weak may cause tissue damage, these injuries are the corresponding immune diseases. Due to the complexity of the immune response, people's understanding of it is limited, the immune substances involved in the immune response are numerous and not specific, and most of them are in the internal organs of the body, which are invisible and intangible, so that low immunity can cause immune diseases, and over-immunity can also cause immune diseases. Our current means of controlling the immune level is very limited, often too high or too low, it is difficult to achieve immune balance, the result is that immune diseases are repeatedly treated and recurring episodes.Immune balance (stability) in the body is the key to ensuring an immune response and the key to treating immune diseases. The immune balance is dynamic, all the time. When the body's immune system (thymus, spleen, bone marrow, lymph, etc.) is healthy, there is no problem with this response. On the contrary, when an immune disease occurs, it is possible that there is a problem with the immune system or an immune organ, which is characterized by immune inflammatory lesions and damage to a certain tissue or organ, which can be classified as autoimmune diseases, rheumatic diseases, allergic diseases, and so on.
Here it is easy to see that in order to cure the immune disease must solve two major problems: first, repair the immune tissue; second, control the site of the disease (immune inflammation) and repair to make it play a normal function.
Research shows that “Goji Huang” acts in the early G1 phase of apoptosis (i.e. G0G1 apoptosis, which is also the apoptosis cycle of stem cells), and its effect shows that it can make the sick cells become normal cells or make the sick cells die, so as to play the purpose of repairing the tissues. The main active ingredient of “Goji Huang” is glycoprotein, which can promote the proliferation of T and B lymphocytes, the increase of interleukin 10 and interleukin 12-P40, interleukin 12-P70, and the correction of the imbalance of auxiliary T lymphocytes, and the results of these experiments tell us that it has anti-inflammatory and immunomodulatory properties, and can continuously increase lymphocytes to ensure an immune balance within the organism. This balance is calm and effective as multiple lymphokines are released within the organism to control inflammation according to the needs of its own tissues. Goji Huang Granules has not been found to have any significant toxic side effects so far.As immune diseases are caused by damage to the body's immune organs or tissues, resulting in a series of immune lesions. By taking Goji Huang Granules the control of clinical symptoms is faster, and it takes time to repair the whole tissue, so for chronic immune diseases it needs to be taken for more than half a year or longer to ensure solid efficacy.
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Sophora japonica fungus, wolfberry, yellow essence
Sophora Fungus: Three major effects (according to Tang Xinxiu Ben Cao)
Cure wind - anti-inflammatory, anti-allergy
Breaking blood - improving microcirculation, removing old tissues
Benefit - enhance immunity, promote tissue repair
Sophora japonica is bitter, pungent and flat in nature, good at benefiting qi and strong, safe and non-toxic, the formula has a large dosage, so it is listed as the king's medicine.
Chinese wolfberry nourishes the kidney, moistens the lung, nourishes the liver and brightens the eyes; Huang Jing nourishes the qi and moistens the eyes; the two herbs are sweet in taste and flat in nature, good at nourishing yin and benefiting the qi, and together they serve as the subject herbs.
Three drugs together, both beneficial and nourishing yin, acacia ear biased in the benefit of gas, goji berries biased in the nourishing yin, Huang Jing qi and yin and complementary, with a party in the complementary and not stagnation of gas, yin but not overly nourishing and greasy, the drug are peaceful, flat tonic qi and yin, flat in the strange. Kidneys hide essence, gas, for the innate nature of this. This formula into the five viscera, viscera related, benefit the essence of the five viscera, nourish the viscera of the Yin Jin, although not much flavor, but the overall weakness of the care of the overall, strong tonic effect.
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Hemolysin antibody (IgM) production in hyper-immunized mice; effect on splenic index in Cy-hyper-immunized QHS mice; effect on proliferative function of T and B lymphocytes in Cy-hyper-immunized QHS mice; effect on IgM production in Cy-induced hyper-immunized SRBC re-immunized mice.
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Numerous studies have shown that the pathological mechanisms of some diseases are mediated by immune abnormalities, such as Sjögren's syndrome [3], in which the function of lymphocytes and their subpopulations are abnormally altered, and the antibody levels are also markedly abnormal, mostly manifested as a decrease in peripheral blood T cells, especially suppressive T (Ts) cells, and a relative increase in helper T (TH) cells, with elevated IgM and IgG levels, accompanied by an antibody-dependent cell-mediated abnormal immune response. IgM and IgG levels are elevated, accompanied by antibody-dependent cell-mediated abnormal immune responses. There are no suitable drugs available for treatment.
In the present study, based on the characteristics of abnormal immune changes in the above diseases, the effects of Goji Huang Granules on non-specific immunity, cellular immunity and humoral immune response were systematically observed by using animal experimental models of normal or abnormal immune response and combining in vivo and ex vivo studies. The study showed that 2 dose groups of Goji Huang granules could significantly promote the phagocytosis function of mouse macrophages, which was beneficial to improve the immune status of the body. DTH is a T-cell-dependent response, which is mainly characterized by a delayed inflammatory response in the sensitized organism at the site of antigenic attack, also known as contact allergic reaction, and the T cells in the DTH response play a key role in autoimmunity and tumor immunity, etc. Therefore, the mouse DTH model is the main animal model representing cellular immune response. The increase or decrease of DTH in mice caused by Cy is an effective way to study the effect of drugs on the regulation of immune function. It has been shown that the application of different doses of Cy at different times of antigen sensitization can have different effects on the immune response. Before antigen sensitization, ip Cy induced a DTH increase model, which was related to the inhibition of Cy-sensitive Ts precursor cells [4, 5, 6], while after antigen sensitization, ip Cy induced a DTH depression model, which was related to the inhibition of lymphocytotoxic response [6, 7]. In the present study, we found that Goji Huang granules 4 and 8 g-kg-1 administered at ig 3 days before sensitization, once a day for 8 consecutive days, could significantly counteract the abnormal or decreased DTH caused by Cy, with obvious bidirectional regulation, and the drug could also significantly restore the abnormally altered thymic index and splenic index, and in vitro studies also found that all three dose groups of the drug could significantly restore the proliferation of T lymphocytes in mice with abnormal DTH. In vitro study also found that all three dose groups of the drug could significantly restore the proliferation of T lymphocytes in mice with abnormal DTH, which may be one of the important mechanisms for its immunomodulatory effect.
The mouse hemolysin antibody production assay is an important animal experimental model representing the humoral immune response [1]. Antibodies appearing after initial immunization with SRBC are mainly of the IgM type, whereas antibodies after re-immunization with SRBC are mainly of the IgG type. However, since the efficiency of IgG hemolysis is considerably lower than that of IgM [8], binding of SRBC alone is not sufficient to activate complement to produce hemolysis, so in our experiments we have utilized a specific anti-Sheep BALB/C mouse hemolysin antibody using the 2-ME, based on the property that 2-ME destroys the IgM antibody but retains the activity of the IgG antibody, to generate hemolysin antibodies. In our experiment, we measured HCIgG based on the principle that sheep anti-BALB/C mouse IgG serum cross-links IgG to produce hemolysis.In the present study, we used Cy as a probe and found that Sophora japonica Huang Granules 8 g-kg-1 could antagonize the increase of splenic IgM production in mice after initial immunization caused by Cy, and it had a down-regulating effect on the proliferation function of T and B lymphocytes in QHS mice with abnormally high levels, which may be one of the important mechanisms for lowering the antibody level. levels, which may be one of the important mechanisms for its reduction of antibody levels. When re-immunized, Cy could increase the production of total Ig and IgG, and the three dose groups of QHS mice could significantly down-regulate the Ig level, which was mainly related to its down-regulation of IgG level. This result suggests that Qihuang granules may have the effect of controlling the formation of autoantibodies.
In conclusion, Goji Huang Granules can not only promote the non-specific immune function, but also have obvious regulating effect on the abnormal alteration of cellular and humoral immune reflections, which can provide an important pharmacological basis for the treatment of autoimmune diseases with Goji Huang Granules.
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Sophora Lycii Granules
Please read the instructions carefully and use according to the instructions or under the guidance of a pharmacist to buy and use!
Drug Name】Generic Name: Huaiqihuang Granules
Hanyu Pinyin: Huaiqihuang Keli
Ingredients】Sophora Ear Clearing Cream, Lycium barbarum, Rhizoma Polygonati Odorati, supplemented with maltodextrin.
Characteristics]: This product is light brown-yellow to brown particles; taste slightly sweet, slightly fishy.
Functions and Indications]: Benefiting qi and nourishing yin. It is suitable for children's weakness caused by deficiency of qi and yin, repeated colds and flu, or the elderly after illness, dizziness, dizziness, fatigue, dry mouth, shortness of breath, palpitation, easy to sweat, loss of appetite, constipation.
Specification] 10g per bag.
Usage and dosage] Take with boiling water. Adults 10-20g (1-2 bags) each time, twice a day; children: 1-3 years old 5g (half a bag), twice a day, 3-12 years old 10g (1 bag), twice a day.
Adverse Reactions] Occasionally, mild diarrhea.
Contraindication] Diabetic patients are forbidden to take.
Precautions
1. Avoid spicy, cold and greasy food.
2. It is not suitable for patients with cold and fever.
3. This product should be taken before meals.
4. Patients with chronic diseases such as hypertension, heart disease, liver disease, kidney disease, etc. should take it under the guidance of a physician.
5. If the symptoms are not relieved after 2 weeks of taking the medicine, you should go to the hospital for consultation.
6. Pregnant women should take under the guidance of a physician.
7. This product is prohibited for those who are allergic to this product, allergic persons should be cautious.
8. The use of this product is prohibited when the properties of the product have changed.
9. Children must be used under adult supervision.
10. Keep this product out of the reach of children.
11. If you are using other drugs, please consult your physician or pharmacist before using this product.
Drug interactions] Drug interactions may occur if used concurrently with other drugs, consult your physician or pharmacist for details.
Storage]: Protected from light, sealed.
Packaging】Composite aluminum plastic film bag. Each box contains 6 bags.
Effective period: 24 months
Execution Standard]: State Drug Administration Drug Standard WS-5067 (B-0067) -2012Z
Approval Number]: State Drug Administration Drug Standard B20020074
Revision date of the instruction manual] March 14, 2024
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Address: No.1166, Nanyuan West Road, Huilong Town, Qidong City, Jiangsu Province, China.
Postal Code: 226200
Phone number 0513-83321533
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Website http://www.gaitianli.com.cn -
1、locust yellow granules is a kind of Chinese medicine?
Goji Huang Granules is made up of three medicines: Sophora japonica fungus, wolfberry, and yellow essence. According to the theory of traditional Chinese medicine, these three drugs together, both beneficial and nourishing yin, replenish the gas without stagnation, nourish the yin but not overly greasy, the medicine are peaceful, flat tonic qi yin, flat in the strange. The weakness of the whole has a comprehensive care, strong tonic effect.
2、locust ear mushroom quality is what kind of medicine? What is the main effect?
Sophora japonica fungus is fermented by the mycelium of Sophora japonica, which plays a key role in ensuring the stability of the drug's efficacy. According to the Tang “Newly Revised Materia Medica”, Sophora Fungus has the three main effects of “treating wind, breaking blood, and benefiting strength”, and these three effects exactly explain the treatment of autoimmune diseases and related immune disease mechanism. Cure wind - anti-inflammatory, anti-allergy; break blood - to improve microcirculation, remove old tissue; benefit - to enhance immunity. Immune diseases are often due to immune disorders and not simply manifested as immune function hypo- or hyper-function, so it brings great difficulties to the treatment. The three main effects of the acacia ear of the wind to solve the immune hyper, Yili to improve immune function, broken blood to remove antigen-antibody complexes, really a rare good medicine.
3、What are the immunomodulatory effects of Sophora japonica mushroom quality tested by modern medicine?
① activate macrophages or neutrophils; ② activate natural killer cells; ③ prompt T-lymphocyte division, proliferation, maturation, differentiation; adjust the ratio of inhibitory and helper T-cells; ④ improve the humoral immunity; ⑤ induce α, γ interferon (induced by the amount of more than 4 times the rise); ⑥ through the production of certain cell activation factors, such as interleukin-2 (IL-2), NK cell activating factor, etc., and then further activate the relevant immune system. (6) through the production of certain cell activating factors, such as interleukin-2 (IL-2), NK cell activating factor, etc., and then further activate the role of the immune cells.
4、Sophora japonica mushroom quality in the immune regulation of what special features?
Generally speaking, the Chinese medicines that support the correctness of the body have a certain immune-enhancing effect and a small amount of immunomodulatory properties. And locust fungus can induce the production of γ interferon, γ interferon's main function is immunomodulatory, which is a rare feature, because the general Chinese medicine can not induce the production of γ interferon.
5、Sophora japonica Huang Granules is composed of three medicines, is its function more complete?
Yes. The mechanism of action of Goji Huang Granules is more comprehensive, from the existing pharmacological proof that it can not only promote non-specific immune function, but also abnormal changes in the cellular and humoral immune response has an obvious regulatory effect, for the Goji Huang Granules for the treatment of autoimmune diseases and immune-related diseases provides an important pharmacological basis.
6、How to understand the treatment of autoimmune diseases and immune-related diseases by Qihuang Granules?
Although the causes of autoimmune diseases and immune-related diseases are complex or multifactorial, the ultimate manifestation is immune disorders, i.e., on the one hand, it manifests as part of hyperimmune function, and at the same time, it manifests as part of hypoimmune function. And Sophora Lycii Granules use two-way immune regulation and overall immune adjustment to change the disorder.
7、Is there any new thinking on the treatment of autoimmune diseases and immune-related diseases?
The exact etiology of autoimmune diseases is still unclear, and the etiology of some of the immune-related diseases is also in doubt. Their therapeutic measures are mainly considered in terms of pathogenesis. The general therapeutic approaches are: (1) elimination of the role of cross-reactive antigens or elimination of factors that alter autoantigens; (2) suppression of immune responses; and (3) suppression of inflammatory processes caused by immune responses, such as the use of adrenocorticotropic hormones. However, the effects of these therapies are not very satisfactory. In recent years, on the basis of in-depth research, some new ideas for treatment have been put forward, in which research is being devoted to the endogenous adjustment of the body's immune regulatory function. Eliminate the various factors that cause abnormal immune response reaction, so as to solve the treatment of related diseases, that is, to adjust the immune, to ensure balance.
8、Is Goji Huang Granules an OTC drug?
Goji Huang Granules is a quasi-nominal drug, but also OTC drugs, OTC drugs show that the effectiveness and safety of the drug is guaranteed.
9、What is the main contribution of Goji Huang Granules in the treatment of immune-related diseases?
From the existing treatment has shown to control, reduce or block the recurrence of this type of disease performance is particularly prominent.
10、Can diabetics use Goji Huang Granules?
Sophora wolfberry granules are made of Sophora japonica fungus, wolfberry and Rhizoma Polygonati Odorati, which are scientifically extracted and then added with appropriate additives, of which a little sucrose has been added to improve the taste, so it should be used with caution or in accordance with the doctor's advice.
11. Can it be used in the acute phase of the disease?
There is no harm in using it in the acute phase, but it must be used in conjunction with related acute phase treatment, such as the use of adrenocorticotropic hormones.
12、Can it be used in both adults and children?
Yes, there is only a difference in dosage. Adults 1 to 2 bags each time, 2 times a day; children: 1 to 3 years old half a bag once, 2 times a day, 3 to 12 years old 1 bag once, 2 times a day.
13、How many treatments should I use?
The drug is used for 15 days as a course of treatment, but 15 days is only to solve some related symptoms of the patient, such as increased appetite, mental improvement, reduction of false sweating in children and so on. As we all know, the treatment of immune-related diseases and autoimmune diseases is a long-term process of endogenous immune adjustment. According to the existing practice, for example, the treatment of asthma in remission requires more than half a year of continuous treatment, while the treatment of “kidney disease” and systemic lupus erythematosus requires more than 2-3 years of continuous treatment.
14. Are there any contraindications?
No, it remains to be seen.
15、Will there be drug resistance in long-term use, is it safe?
No drug resistance has been found. Acute toxicity test and long-term toxicity test have not found toxicity, so that the use of the drug is safe.
16、from the acai qi huang granules treatment of kidney disease so that the blood creatinine index decline, the renal function of the chronic kidney and renal tissue has a repair function, what is the reason for this?
In addition to anti-inflammatory and immunomodulatory functions, Goji Huang Granules also has: (a) G0/G1 phase apoptosis of mitochondrial pathway. This phase of apoptosis has two characteristics: 1. let the sick cells repair into normal cells; 2. let the diseased cells that can not be repaired die. So it has a strong repair function. (ii) The feature of activating blood circulation and removing blood stasis. Many microcirculation in diseased tissues have circulatory embolism, which seriously cause local tissue necrosis, while activating blood circulation and removing blood stasis solves the problem of getting rid of obsolete tissues and promotes the repair of tissues.
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