Interpretation of the latest version of the "liver cancer diagnosis and treatment norms", the anti-cancer effect of traditional Chinese medicine has been approved by foreign scholars!

Primary liver cancer is the fourth common malignant tumor in China, and the second cause of cancer death, which seriously threatens the life and health of our people. The difficulty of liver cancer prevention and treatment is not only that it is not easy to detect early-most liver cancer patients miss the best time for early diagnosis and treatment because they do not pay attention to regular physical examination, and often see a doctor after symptoms appear, which is mostly in the middle and late stage of liver cancer. Moreover, the recurrence rate of liver cancer after surgical radical resection is relatively high, which is still a problem that must be paid attention to at this stage. Reasonable and effective measures should be taken to prevent tumor recurrence and metastasis, including intervention, drugs, etc.; in addition, because most liver cancer patients are in the middle and late stages of treatment, although targeted drugs and immunotherapy are research hotspots in recent years, the expensive treatment costs have discouraged many people, and Chinese medicine can just play an important role!

《Standard for diagnosis and treatment of primary liver cancer (2019 edition)"is based on the latest clinical evidence in the diagnosis, staging and treatment of liver cancer in recent years, especially the research results adapted to China's national conditions 《Standard for Diagnosis and Treatment of Primary Liver Cancer (2017 Edition)"On the basis, it is revised and updated by multidisciplinary experts in the field of liver cancer organized by the Oncology Branch of the Chinese Medical Association, and publicly released by the Medical Administration and Hospital Administration of the National Health Commission. It is the most authoritative guide in the field of liver cancer diagnosis and treatment in China (hereinafter referred to as the" Specification ").

1. improve the efficacy of liver cancer, we must first strengthen the regular monitoring and screening of high-risk groups of liver cancer:

The screening of high-risk groups of liver cancer is helpful to the early detection, early diagnosis and early treatment of liver cancer, which is the key to improve the curative effect of liver cancer. The Code points out that in China, the high-risk groups of liver cancer mainly include: people with hepatitis B virus (Hepatitis B virus,HBV) and (or) hepatitis C virus (Hepatitis C virus,HCV) infection, excessive drinking, non-alcoholic steatohepatitis, long-term consumption of food contaminated by aflatoxin, liver cirrhosis caused by various other reasons, and family history of liver cancer, in particular, men aged> 40 are at greater risk.

Screening methods: mainly by means of liver ultrasound and serum alpha-fetoprotein (Alpha-fetoprotein,AFP) for early screening of liver cancer; screening frequency: it is recommended that high-risk groups be checked at least every 6 months.

Ultrasound examination is the most commonly used liver imaging examination method in clinical practice. Experienced ultrasound doctors can detect intrahepatic space-occupying lesions in the early stage by ultrasound and differentiate and diagnose liver tumors of different nature by contrast-enhanced ultrasound examination. Once liver malignant tumor is suspected, further liver enhanced CT and nuclear magnetic resonance (MRI) examination are needed, among which CT can be used for clinical diagnosis and staging of liver cancer, multimodal MRI is better than enhanced CT in the diagnosis of liver cancer, especially the extremely early liver cancer with diameter ≤ 1.0cm can be detected by using hepatocyte specific contrast agent gadolinium disodium (Gd-EOB-DTPA). When serum AFP ≥ 400 μg/L, pregnancy, chronic or active liver disease, gonadal embryogenic tumor and digestive tract tumor are excluded, which is highly suggestive of liver cancer. Dynamic observation should be carried out for patients with slightly elevated serum AFP..

2. improve the curative effect of liver cancer, it is emphasized that standardized treatment should be carried out according to the stage of liver cancer:

Many liver cancer patients are often confused after diagnosis, do not know how to treat, the answer to different hospitals are not the same, in the end the choice of which treatment? The emergence of liver cancer staging is to solve this problem, which is crucial for the prognosis assessment, the choice of reasonable treatment options. There are many staging programs abroad, such as BCLC, TNM, JSH, APASL, etc. Now we also have the Chinese liver cancer staging program (China liver cancer staging, CNLC), according to the patient's general condition, liver function, presence or absence of extrahepatic metastasis, vascular invasion, tumor number and size It is the same as the other three times.

Surgical treatment, including liver resection and liver transplantation, is the most important means for long-term survival of liver cancer patients-CNLC stage Ia, Ib and IIa liver cancer with good liver reserve function is the preferred indication for surgical resection, CNLC stage IIb and IIIa liver cancer patients, if properly selected, can also choose surgical resection through careful preoperative evaluation;

Transarterial chemoembolization (Transarterial chemoembolization,TACE) is currently recognized as one of the most commonly used methods for patients with liver cancer not suitable for surgery. It can be used for the treatment of patients with CNLC IIb, IIIa and some IIIb liver cancer, portal vein tumor thrombus, hepatic artery-portal vein shunt, and recurrence after liver cancer resection.

For patients with advanced liver cancer, targeted drug therapy may shrink the tumor, improve symptoms and prolong survival time, but the overall effect is not ideal. It can be used for CNLC IIIa and IIIb with vascular invasion or extrahepatic metastasis, portal vein trunk or inferior vena cava tumor thrombus, and liver cancer progressing after TACE. The first-line targeted drugs already listed in China areSorafenibandLenvatinib, second-line targeted drugs areregorafenib;PD-1It belongs to immunotherapy and can be combined with targeted drugs, chemotherapy drugs, local treatment, etc.

What kind of drugs are included in the "norms" twice in 3?

As mentioned earlier, there are two difficulties in the treatment of liver cancer. The first is to prevent the recurrence of liver cancer after surgical resection, and the second is the treatment of advanced liver cancer. The same drug is mentioned twice in the Code--Huaier GranulesThere are "bright spots" in the two difficulties of liver cancer treatment "! Not only that, Huaier Granules have also been included in another national authoritative guide-"Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2018 Edition)" compiled by the Chinese Society of Clinical Oncology (CSCO).

1) Huaier granule can reduce the recurrence of liver cancer after resection and prolong the survival time of patients!

According to the "standard" data, the tumor recurrence and metastasis rate is as high as 40-70% in 5 years after liver cancer resection, which is related to the small spread foci or multi center occurrence that may exist before operation. In addition to close follow-up, for patients with high risk of recurrence, a study result shows that patients with high risk of recurrence are accepted after liver resectionHuaier GranulesTreatment can reduce recurrence and prolong patient survival (Level of Evidence 1). The so-called evidence level 1 refers to the evidence obtained through well-designed randomized controlled clinical trials. It is the most scientific and accurate result in drug clinical trials. This is also the strongest support obtained by Chinese medicine in the treatment of liver cancer so far!

2) Patients with advanced liver cancer can also use Huaier granules!

"Standard" is committed to tapping the potential of traditional Chinese medicine, especially in the systematic treatment of advanced liver cancer, traditional Chinese medicine treatment can improve clinical symptoms, improve the body's resistance, reduce the adverse reactions of radiotherapy and chemotherapy, and improve the quality of life of patients. In addition to the use of traditional syndrome differentiation and treatment, taking decoction, China's drug regulatory authorities have approved a number of modern Chinese medicine preparations, suchHuaier GranulesThe compliance, safety and tolerability of patients were good.

4. Huaier granule anti-liver cancer effect, really have so magical? Look at foreign scholars and made what research results?

1)Huaier GranulesReduce the postoperative recurrence rate of liver cancer33%!

This is a large-scale clinical trial jointly carried out by 39 tertiary hospitals across the country. A total of 1044 patients who underwent liver cancer resection were recruited from 2011 to 2014. The experimental group took oral administration 3 times a dayHuaier Granules20g, after 2 years of follow-up, it was found that takingHuaier GranulesNot only the vast majority of patients are still alive, but the recurrence rate is also significantly reduced.

It is this study that confirmsHuaier GranulesIt can be used as an adjuvant treatment for liver cancer after surgery, and regardless of whether there is hepatitis B infection, cirrhosis, ascites, etc. when the patient starts taking the medicine,Huaier GranulesThe effects are quite stable. This research result has been included in the European Journal of Gastroenterology, which is the most authoritative medical journal in the world, ranking second in the world in the journals of gastroenterology and hepatology. It can be included in such journals. It also confirms that the data of this study are true and objective.

2) the medicinal fungus Huaier, has been used for anti-cancer treatment for thousands of years!

Sophora japonica ear is one of basidiomycetes Agarata, which was first discovered by Li Shizhen, a famous medical scientist in the Ming Dynasty of China. Some people also suggested that Sophora japonica ear was mentioned in "Elbow Reserve Emergency Prescription" as early as the Eastern Jin Dynasty. Sophora japonica ear and its extracts are widely used in traditional Chinese medicine treatment, especially in anti-cancer treatment, the active ingredient of Sophora japonica showed as a light yellow powder.

Huaier GranulesIt was approved in 1992 for the treatment of advanced liver cancer. Its main component is water-soluble polysaccharide. The monosaccharide composition of the polysaccharide protein is fucose, arabinose, galactose, glucose, xylose and mannose. Plant polysaccharides can enhance the body's immune ability by binding to cell surface receptors (including CD14, CR3, Toll-like receptors, scavenger receptors and Dectin-1).

3) Japanese scholars foundHuaier GranulesHas the function of promoting tumor gene recovery!

In addition to previous clinical and laboratory studies suggest that Huaier has anti-tumor activity by inhibiting the expression of vascular endothelial cytokines and preventing tumor angiogenesis, Huaier can also induce cell cycle arrest at G0/G1 phase, activate the apoptotic protease cascade and destroy the mitochondrial function of tumor cells.

Japanese scholars found in the latest research that the molecular basis of the Huaier effect is based on the influence on Hippo signaling pathway, which promotes the normalization of transcriptional regulation of damaged cells and is conducive to the recovery of body balance. In fact, this is also the theoretical basis of syndrome differentiation and treatment such as "strengthening the body and eliminating evil", "detoxification and removing blood stasis" and "balance of yin and yang" proposed in traditional Chinese medicine anti-tumor, after collecting and analyzing RNA information of patients using Huaier before and after treatment, Japanese scholars found that after 28 days of treatment, more than 4000 genes of patients had changed, suggesting that Huaier could have an effect on the immune system, nervous system, cell proliferation, endocrine system and so on.

Conclusion

The continuous updating of the "standard" has played an important role in standardizing the clinical behavior of liver cancer diagnosis and treatment in China, improving the prognosis of liver cancer patients, ensuring medical quality and medical safety, and optimizing medical resources. The clinical data and results of Huaier particles are undoubtedly a great leap in the field of traditional Chinese medicine in the treatment of liver cancer, which can not only reduce the clinical symptoms and prolong the survival period of patients, There are also exact data that it can reduce the recurrence of liver cancer.

Huaier, a gift from nature, is a modern medicine that has extracted effective ingredients through modern medical technology. It is also quietly waiting for people to slowly tap more magical effects of itself; this not only further proves the great potential of Chinese medicine in the treatment of liver cancer, but also Inspiration for the modern research and development direction of Chinese medicine is to standardize the treatment of Chinese medicine through standardized and in-depth scientific clinical experiments and practices, we also look forward to more and better Chinese medicine to make up for the loopholes in modern medicine.